Prognostic value of cancer-associated fibroblasts-related genes in lung adenocarcinoma.

ABSTRACT:

Background

The incidence of lung adenocarcinoma is in the forefront of malignant tumors in the world. The purpose of this study was to investigate the role of cancer-associated fibroblast-related genes (CAFRGs) in the occurrence, diagnosis and development of lung adenocarcinoma.

Methods

RNA data and corresponding clinical information of lung adenocarcinoma patients were acquired from The Cancer Genome Atlas (TCGA) database. Consensus clustering was performed to identify different molecular subgroups. The tumor immune states of different subgroups were determined by Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE; https://bioinformatics.mdanderson.org/estimate/index.html), microenvironment cell populations (MCP)-counter (which

SUBMITTER: Li W 

PROVIDER: S-EPMC10493796 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature