Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy.

ABSTRACT: Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME. Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules. We will review recent advancements in nanomedical applications and discuss specifically designed nanocompos

SUBMITTER: Sharma P 

PROVIDER: S-EPMC10494322 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature