Impact of CD40 gene polymorphisms on the risk of cervical squamous cell carcinoma: a case-control study.

ABSTRACT:

Background

Cervical cancer is the fourth most common cancer among women worldwide. Genome-wide association studies have revealed multiple susceptible genes and their polymorphisms for cervical cancer risk. Therefore, we aimed to investigate the correlation between single nucleotide polymorphisms (SNPs) of the CD40 gene and susceptibility to cervical squamous cell carcinoma (CSCC) in a population from the northeastern Han Chinese population.

Methods

The three SNPs (rs1800686, rs3765459, and rs4810485) of the CD40 gene were analyzed by multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods in 421 patients with CSCC, 594 patients with high-grade squamous intraepithelial lesions (HSIL), and 504 healthy females. Multivariate logistic regression

SUBMITTER: Zhu M 

PROVIDER: S-EPMC10494347 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature