The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study.

ABSTRACT:

Background

The role of thyroid hormones in cancers has been discussed in observational studies; however, the causal relationship between them remains controversial.

Methods

The SNPs associated with hypothyroidism and hyperthyroidism were selected from a FinnGen biobank of 342,499 (190,879 females and 151,620 males) Finnish adult subjects. Data from the Thyroidomics Consortium on 72,167 individuals were used to assess genetically determined thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Lung cancer, lung adenocarcinoma and squamous cell lung cancer GWAS data from the International Lung Cancer Consortium(ILCCO). Six different Mendelian randomization (MR) Methods, including Inverse variance weighted (IVW), MR-Egger, Simple mode, MR-Pleiotropy Residual Sum and Outli

SUBMITTER: Wang X 

PROVIDER: S-EPMC10494366 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature