Portraying the dark side of endogenous IFN-λ for promoting cancer progression and immunoevasion in pan-cancer.

ABSTRACT:

Background

IFN-λ has been shown to have a dual function in cancer, with its tumor-suppressive roles being well-established. However, the potential existence of a negative ''tumor-promoting'' effect of endogenous IFN-λ is still not fully understood.

Methods

We conducted a comprehensive review and analysis of the perturbation of IFN-λ genes across various cancer types. Correlation coefficients were utilized to examine the relationship between endogenous IFN-λ expression and clinical factors, immune cell infiltration, tumor microenvironment, and response to immunotherapy. Genes working together with IFN-λ were obtained by constructing the correlation-based network related to IFN-λ and the gene interaction network in the KEGG pathway and IFN-λ-related genes obtained from the net

SUBMITTER: Wang ZZ 

PROVIDER: S-EPMC10494394 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature