Purifying selection leads to low protein diversity of the mitochondrial cyt b gene in avian malaria parasites.

ABSTRACT:

Background

Mitochondrial respiration plays a central role in the survival of many eukaryotes, including apicomplexan parasites. A 479-bp fragment from the mitochondrial cytochrome b gene is widely used as a barcode to identify genetic lineages of avian malaria parasites Plasmodium and related haemosporidians. Here we looked for evidence of selection in the avian Plasmodium cyt b gene, using tests of selection and protein structure modeling. We also tested for the association between cyt b polymorphism and the host specificity of these parasites.

Results

Based on 1,089 lineages retrieved from the Malavi database, we found that the frequency of the most conserved amino acids in most sites was more than 90%, indicating that the protein diversity of the avian Plasmodium cyt b ba

SUBMITTER: Wang X 

PROVIDER: S-EPMC10494422 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature