Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value.

ABSTRACT:

Background

Approximately 40% of colorectal cancer (CRC) cases are linked to Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. KRAS mutations are associated with poor CRC prognosis, especially KRAS codon 12 mutation, which is associated with metastasis and poorer survival. However, the clinicopathological characteristics and prognosis of KRAS codon 13 mutation in CRC remain unclear.

Aim

To evaluate the clinicopathological characteristics and prognostic value of codon-specific KRAS mutations, especially in codon 13.

Methods

This retrospective, single-center, observational cohort study included patients who underwent surgery for stage I-III CRC between January 2009 and December 2019. Patients with KRAS mutation status

SUBMITTER: Ahn HM 

PROVIDER: S-EPMC10494767 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature