Dataset Information

Agarose Gel: An Overview of the Dermal Filler and a Clinical Experience With 700 Patients.

ABSTRACT:

Background

Dermal fillers currently in the market have several advantages and disadvantages over each other. Agarose gel (AG) is a unique material due to its special rheological characteristics and gel-forming capability.

Objectives

The authors aimed to share their clinical experience on AG for a variety of facial augmentation procedures and its long-term results.

Methods

The study population consisted of 700 patients (532 females; 168 males) aged 18 to 52 years. Follow-up visits were at 1, 3, 6, 12, and 24 months after the injections. Patient satisfaction was evaluated on a scale from 0 to 10 using a survey and clinical improvement was evaluated using the Global Aesthetic Improvement Scale (GAIS) by 2 independent plastic surgeons before the injection and at 1-year follow-up.

Results

Eighty-two percent of the patients scored 1 or 2 (exceptional or great improvement) on GAIS. Eighty-five percent of the patients scored 8 or above (very satisfied). Most patients experienced at least 80% persistence of effect at 1-year follow-up.

Conclusions

AG appears to be suitable for a variety of facial augmentation and contouring applications, as it is safe and has long-lasting favorable cosmetic efficacy.

Level of evidence 3

SUBMITTER: Buhsem O

PROVIDER: S-EPMC10494782 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Agarose Gel: An Overview of the Dermal Filler and a Clinical Experience With 700 Patients.

Buhsem Omer O Kirazoglu Ahmet A

Aesthetic surgery journal. Open forum 20230614

<h4>Background</h4>Dermal fillers currently in the market have several advantages and disadvantages over each other. Agarose gel (AG) is a unique material due to its special rheological characteristics and gel-forming capability.<h4>Objectives</h4>The authors aimed to share their clinical experience on AG for a variety of facial augmentation procedures and its long-term results.<h4>Methods</h4>The study population consisted of 700 patients (532 females; 168 males) aged 18 to 52 years. Follow-up ...[more]

PMID: 37700788

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Project description:Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established. Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application. Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used. Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85-0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66-0.82) and 46% (ES = 0.46, 95% CI:0.28-0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger.

Dataset Information

Agarose Gel: An Overview of the Dermal Filler and a Clinical Experience With 700 Patients.

Background

Objectives

Methods

Results

Conclusions

Level of evidence 3

Publications

Agarose Gel: An Overview of the Dermal Filler and a Clinical Experience With 700 Patients.

Similar Datasets

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