Spatial Cluster Patterns of Retinal Sensitivity Loss in Intermediate Age-Related Macular Degeneration Features.

ABSTRACT:

Purpose

To examine spatial patterns of retinal sensitivity loss in the three key features of intermediate age-related macular degeneration (iAMD).

Methods

One-hundred individuals (53 iAMD, 47 normal) underwent 10-2 mesopic microperimetry testing in one eye. Pointwise sensitivities (dB) were corrected for age, sex, iAMD status, and co-presence of co-localized key iAMD features: drusen load, pigmentary abnormalities, and reticular pseudodrusen (RPD). Clusters (labeled by ranks of magnitude C-2, C-1, C0) were derived from pointwise sensitivities and then assessed by quadrants and eccentricity/rings.

Results

Two clusters of decreased sensitivities were evident in iAMD versus normal: C-2, -1.67 dB (95% CI (confidence intervals), -2.36 to -0.98; P < 0.0001); C-1, -0.93 dB (

SUBMITTER: Trinh M 

PROVIDER: S-EPMC10494986 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature