Evolution of Plasmodium vivax and resistance patterns for infection based on Duffy genotype and phenotype.

ABSTRACT: The Duffy protein, a transmembrane molecule, acts as a receptor for various chemokines and facilitates binding between reticulocytes and the Plasmodium Duffy antigen binding protein. Duffy expression is associated with the Duffy chemokine receptor antigen genotype on chromosome 1 and exhibits variation across different geographic regions. Traditionally, the Duffy negative genotype and phenotype have been described to confer a certain level of protection against infection and symptom development. However, recent data suggest a shift in this behavior, with significantly higher prevalence observed in individuals with Duffy negative genotype or phenotype. Given that malaria is an endemic vector-borne disease in regions of Asia, Africa, and Latin America, posing a substantial global burd

SUBMITTER: Picon-Jaimes YA 

PROVIDER: S-EPMC10495050 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature