Transcript levels of 4 genes in umbilical cord blood are predictive of later autism development: a longitudinal follow-up study.

ABSTRACT:

Background

Over recent decades, autism spectrum disorder (ASD) has been of increasing epidemiological importance, given the substantial increase in its prevalence; at present, clinical diagnosis is possible only after 2 years of age. In this study, we sought to develop a potential predictive model for ASD screening.

Methods

We conducted a longitudinal follow-up study of newborns over 3 years. We measured transcript levels of 4 genes (superoxide dismutase-2 [SOD2], retinoic acid-related orphan receptor-α [RORA], G protein-coupled estrogen receptor-1 [GPER], progesterone receptor [PGR]), 2 oxidative stress markers and epigenetic marks at the RORA promoter in case-control umbilical cord blood mononuclear cell (UCBMC) samples.

Results

We

SUBMITTER: Jia Q 

PROVIDER: S-EPMC10495168 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature