CT-derived extracellular volume and liver volumetry can predict posthepatectomy liver failure in hepatocellular carcinoma.

ABSTRACT:

Objectives

Posthepatectomy liver failure (PHLF) is a severe complication of liver resection. We aimed to develop and validate a model based on extracellular volume (ECV) and liver volumetry derived from computed tomography (CT) for preoperative predicting PHLF in resectable hepatocellular carcinoma (HCC) patients.

Methods

A total of 393 resectable HCC patients from two hospitals were enrolled and underwent multiphasic contrast-enhanced CT before surgery. A total of 281 patients from our hospital were randomly divided into a training cohort (n = 181) and an internal validation cohort (n = 100), and 112 patients from another hospital formed the external validation cohort. CT-derived ECV was measured on nonenhanced and equilibrium phase images, and liver volumetry was measured

SUBMITTER: Peng Y 

PROVIDER: S-EPMC10495294 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature