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Three new amide derivatives from the fungus Alternaria brassicicola.

ABSTRACT: Three new amide derivatives (alteralkaloids A-C, 1-3) and three known alkaloids (4-6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1-3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity.

SUBMITTER: Li F

PROVIDER: S-EPMC10495297 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Three new amide derivatives from the fungus Alternaria brassicicola.

Li Fengli F Gu Saisai S Zhang Sitian S Mo Shuyuan S Guo Jieru J Hu Zhengxi Z Zhang Yonghui Y

Natural products and bioprospecting 20230911 1

Three new amide derivatives (alteralkaloids A-C, 1-3) and three known alkaloids (4-6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1-3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic si ...[more]

PMID: 37695377

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