Estimation of relative biological effectiveness of ²²⁵Ac compared to ¹⁷⁷Lu during [²²⁵Ac]Ac-PSMA and [¹⁷⁷Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS.

ABSTRACT:

Aim

Over recent years, [²²⁵Ac]Ac-PSMA and [¹⁷⁷Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced prostate cancer. Especially for alpha particle emitter treatments, there is still a need for improving dosimetry, which requires accurate values of relative biological effectiveness (RBE). To achieve that, consideration of DNA damages in the cell nucleus and knowledge of the energy deposition in the location of the DNA at the nanometer scale are required. Monte Carlo particle track structure simulations provide access to interactions at this level. The aim of this study was to estimate the RBE of ²²⁵Ac compared to ¹⁷⁷Lu. The initial damage distribution after radionuclide decay and the residual dama

SUBMITTER: Rumiantcev M 

PROVIDER: S-EPMC10495309 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature