CD8⁺ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types.

ABSTRACT: Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8⁺ memory T cells develop at the location of infection: tissue-resident memory T cells (T_RM). CD8⁺ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (T_REG) are important for CD8⁺ T-cell development, however, if CD8⁺ T_RM cells develop under other infection types and require immune type-specific T_REG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8⁺ T_RM cells. Intracellular (type-1) and extracellular

SUBMITTER: Barros L 

PROVIDER: S-EPMC10495327 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature