CBX4 deletion promotes tumorigenesis under Kras^G12D background by inducing genomic instability.

ABSTRACT: Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 has been shown to have diverse, even opposite functions in different types of tissue and malignancy in previous studies. In this study, we found that CBX4 deletion promoted lung adenocarcinoma (LUAD) proliferation and progression in Kras^G12D mutated background. In vitro, over 50% Cbx4^L/L, Kras^G12D mouse embryonic fibroblasts (MEFs) underwent apoptosis in the initial period after Adeno-Cre virus treatment, while a small portion of survival cells got increased proliferation and transformation abilities, which we called select

SUBMITTER: Chen F 

PROVIDER: S-EPMC10495400 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature