Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.

ABSTRACT: The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has provided crucial protection against SARS-CoV-2. Neutralising antibody (nAb) responses are a key correlate of protection, and therefore measuring nAb responses is essential for monitoring vaccine efficacy. Fingerstick dried blood spots (DBS) are ideal for use in large-scale sero-surveillance because they are inexpensive, offer the option of self-collection and can be transported and stored at ambient temperatures. Such advantages also make DBS appealing to use in resource-limited settings and in potential future pandemics. In this study, nAb responses in sera, venous blood and fingerst

SUBMITTER: Roper KJ 

PROVIDER: S-EPMC10495436 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature