Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.

ABSTRACT:

Introduction

Neurological deterioration, soon after anti-copper treatment initiation, is problematic in the management of Wilson's disease (WD) and yet reports in the literature are limited. The aim of our study was to systematically assess the data according to early neurological deteriorations in WD, its outcome and risk factors.

Methods

Using PRISMA guidelines, a systematic review of available data on early neurological deteriorations was performed by searching the PubMed database and reference lists. Random effects meta-analytic models summarized cases of neurological deterioration by disease phenotype.

Results

Across the 32 included articles, 217 cases of early neurological deterioration occurred in 1512 WD patients (frequency 14.3%), most commonly in patients wi

SUBMITTER: Antos A 

PROVIDER: S-EPMC10495500 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature