Ontology highlight
ABSTRACT:
SUBMITTER: Jain K
PROVIDER: S-EPMC10495550 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Jain Kshama K Mohan K Varsha KV Roy Gargi G Sinha Prakriti P Jayaraman Vignesh V Kiran Yadav Ajit Singh AS Phasalkar Akshay A Deepanshu Pokhrel Anupa A Perumal Nagarajan N Sinha Nitin N Chaudhary Kiran K Upadhyay Pramod P
Scientific reports 20230911 1
Sepsis is caused by dysregulated immune response to severe infection and hyper inflammation plays a central role in worsening the disease. The immunomodulatory properties of mesenchymal stem cells (MSCs) have been evaluated as a therapeutic candidate for sepsis. Reconditioned monocytes (RM), generated from healthy human peripheral blood mononuclear cells (PBMCs) exhibit both macrophage and MSCs-like properties. RM were administered at different stages of sepsis in a mouse model. It reduced serum ...[more]