Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice.

ABSTRACT: Introduction: Inflammation is a defensive response of the body and the pathological basis of many diseases. However, excessive inflammation and chronic inflammation impair the homeostasis of the organism. Arachidonic acid (AA) has a close relationship with inflammation and is the main mediator of the pro-inflammatory response. Based on the prodrug principle, the new pharmaceutical compound aspirin eugenol ester (AEE) was designed and synthesized. However, the effects of AEE on key enzymes, metabolites and inflammatory signaling pathways in the AA metabolic network have not been reported. Methods: In this study, the anti-inflammation effects of AEE were first investigated in mice and RAW264.7 cells in LPS induced inflammation model. Then, the changes of the key enzymes and AA

SUBMITTER: Liu X 

PROVIDER: S-EPMC10495573 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature