Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma.

ABSTRACT:

Background

FDG PET/CT is a tool for assessing response to therapy in various cancers, and may provide an earlier biomarker of clinical response. We developed a novel semi-automated approach for analyzing FDG PET/CT images in patients with multiple myeloma (MM) to standardize FDG PET application.

Methods

Patients (n = 8) with relapsed/refractory MM from the Phase 2 study (NCT02899052) of venetoclax plus carfilzomib and dexamethasone underwent FDG PET/CT at baseline and up to two timepoints during treatment. Images were processed using an established automated segmentation algorithm, with the modification that a red marrow region in an unaffected lumbar vertebra was used to define background standardized uptake value normalized to lean body mass (SUL) threshold above which upt

SUBMITTER: Wellman TJ 

PROVIDER: S-EPMC10495672 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature