Lipid alternations in the plasma of COVID-19 patients with various clinical presentations.

ABSTRACT:

Background

COVID-19 is a highly infectious respiratory disease that can manifest in various clinical presentations. Although many studies have reported the lipidomic signature of COVID-19, the molecular changes in asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals remain elusive.

Methods

This study combined a comprehensive lipidomic analysis of 220 plasma samples from 166 subjects: 62 healthy controls, 16 asymptomatic infections, and 88 COVID-19 patients. We quantified 732 lipids separately in this cohort. We performed a difference analysis, validated with machine learning models, and also performed GO and KEGG pathway enrichment analysis using differential lipids from different control groups.

Results

We found 175 different

SUBMITTER: Liang X 

PROVIDER: S-EPMC10495680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature