Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry.

ABSTRACT:

Aims

Renal denervation has been shown to lower blood pressure in sham-controlled trials and represents a device-based treatment option for hypertension. We sought to project clinical event reductions after radiofrequency renal denervation using a novel modelling approach.

Methods and results

The Global SYMPLICITY Registry is a global, prospective all-comer registry to evaluate safety and efficacy after renal denervation. For this analysis, change in office systolic blood pressure from baseline was calculated from reported follow-up in the Global SYMPLICITY Registry. Relative risks for death and other cardiovascular events as well as numbers needed to treat for event avoidance were obtained for the respective blood pressure reductions based on previously reported meta-regress

SUBMITTER: Schmieder RE 

PROVIDER: S-EPMC10495746 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature