Clinical Exome Gene Panel Analysis of a Cohort of Urothelial Bladder Cancer Patients from Sri Lanka.

ABSTRACT:

Background

Bladder cancer has a high rate of recurrence and high mortality rates in those who progress to muscle invasive disease. Biomarkers and molecular sub classification of tumours beyond standard histopathology has been proposed to address therapeutic dilemmas. The Cancer Genome Atlas project and other studies have contributed to the enhanced knowledge base of the mutational landscape of urothelial bladder cancer. Once again, these are mostly from Caucasian and Chinese patients, with data from the rest of Asia and Sri Lanka being sparse. The objective of this study was to assess the genomic variations of a cohort of urothelial bladder cancer patients in Sri Lanka.

Methods

The molecular genetic study was conducted on formalin fixed paraffin embedded tumour samples of 24

SUBMITTER: Malalasekera A 

PROVIDER: S-EPMC10495915 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature