Gut microbial change after administration of Lacticaseibacillus paracasei AO356 is associated with anti-obesity in a mouse model.

ABSTRACT:

Introduction

The status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and prevention of obesity and related gut microbial dysbiosis. The anti-obesity effect of Lacticaseibacillus paracasei AO356 was recently reported. However, the effect of L. paracasei AO356 on the gut microbiota has not yet been identified. This study aimed to elucidate the effect of L. paracasei AO356 on gut microbiota and ensure its safety for use as a probiotic.

Methods

Oral administration of L. paracasei AO356 (10⁷ colony-forming units [CFU]/mg per day, 5 days a week, for 10 weeks) to mice fed

SUBMITTER: Song EJ 

PROVIDER: S-EPMC10496115 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature