Treatment outcomes in major depressive disorder in patients with comorbid alcohol use disorder: A STAR*D analysis.

ABSTRACT:

Introduction

Guidance on Major Depressive Disorder (MDD) treatment in those with comorbid Alcohol Use Disorder (AUD) is limited. We performed a secondary analysis on the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, examining the association between comorbid AUD and depression outcomes.

Methods

STAR*D was a real-world effectiveness trial starting with citalopram in level 1. Non-responding participants progressed through 3 other sequential treatment levels with different switch or augmentation options. Antidepressant outcomes were compared between MDD (n = 2826) and comorbid MDD and AUD (n = 864). Logistic regressions were performed to evaluate remission and response predictors in the total STAR*D sample and the AUD-comorbidity interaction.

Results

SUBMITTER: Tang VM 

PROVIDER: S-EPMC10496139 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature