Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders.

ABSTRACT:

Background

Recently, a systematic review and meta-analysis demonstrated that overexpression of p53 immunoprotein was significantly associated with progression risk of oral potentially malignant disorders (OPMD). However, the results of investigations on TP53 genetic typing in OPMD were inconsistent and inconclusive.

Methods

A systematic evaluation was conducted to identify all eligible case-control studies on the association of TP53 codon 72 polymorphism with both onset and progression of OPMD.

Results

A total of 768 OPMD patients and 1173 healthy individuals were identified from 12 eligible case-control studies on TP53 codon 72 polymorphism OPMD onset. In overall and subgroup analyses, no significantly risk of OPMD onset was observed in the cases for genetic models i

SUBMITTER: Li H 

PROVIDER: S-EPMC10496165 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature