Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.

ABSTRACT:

Backgorund

While various endometrial biomarkers have been characterized at the transcriptomic and functional level, there is generally a poor overlap among studies, making it unclear to what extent their upstream regulators (e.g., ovarian hormones, transcription factors (TFs) and microRNAs (miRNAs)) realistically contribute to menstrual cycle progression and function. Unmasking the intricacies of the molecular interactions in the endometrium from a novel systemic point of view will help gain a more accurate perspective of endometrial regulation and a better explanation the molecular etiology of endometrial-factor infertility.

Methods

An in-silico analysis was carried out to identify which regulators consistently target the gene biomarkers proposed in studies related to endom

SUBMITTER: Parraga-Leo A 

PROVIDER: S-EPMC10496172 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature