APOE-ε4 and BIN1 increase risk of Alzheimer's disease pathology but not specifically of Lewy body pathology.

ABSTRACT: Lewy body (LB) pathology commonly occurs in individuals with Alzheimer's disease (AD) pathology. However, it remains unclear which genetic risk factors underlie AD pathology, LB pathology, or AD-LB co-pathology. Notably, whether APOE-ε4 affects risk of LB pathology independently from AD pathology is controversial. We adapted criteria from the literature to classify 4,985 subjects from the National Alzheimer's Coordinating Center (NACC) and the Rush University Medical Center as AD-LB co-pathology (AD⁺LB⁺), sole AD pathology (AD⁺LB^-), sole LB pathology (AD^-LB⁺), or no pathology (AD^-LB^-). We performed a meta-analysis of a genome-wide association study (GWAS) per subpopulation (NACC/Rush) for each disease p

SUBMITTER: Talyansky S 

PROVIDER: S-EPMC10496176 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature