Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses.

ABSTRACT:

Background

Equine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According to the most recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, insulin resistance and diabetes, and may contribute to overall metabolic dysregulations. This study aimed to test whether exogenous SHBG could protect EMS affected adipose-derived stromal stem cells (EqASC_EMS) from apoptosis, oxidative stress, ER stress and thus improve insulin sensitivity.

Methods

EqASC_EMS wells were treated with two different concentrations (50 and 100 

SUBMITTER: Bourebaba N 

PROVIDER: S-EPMC10496240 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature