Clinical implications and immune features of CENPN in breast cancer.

ABSTRACT:

Background

A number of human diseases have been associated with Centromere protein N (CENPN), but its role in breast cancer is unclear.

Methods

A pan-cancer database of Genotype Tissue Expression (GTEx) and the Cancer Genome Atlas (TCGA) were used to examine the expression of CENPN. Using TCGA clinical survival data and breast cancer specimens from our center for validation, the relationship between CENPN expression, breast cancer prognosis, and clinicopathological characteristics of patients was examined. Bioinformatics was utilized to conduct an enrichment study of CENPN. Additionally, the potential of CENPN as a predictive biomarker for immunotherapy success was confirmed by analyzing the co-expression of CENPN with immune-checkpoint related genes, reviewing the TCGA data

SUBMITTER: Gui Z 

PROVIDER: S-EPMC10496242 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature