Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis.

ABSTRACT:

Background

Few studies have investigated associations between adiposity and reproductive factors using causal methods, both of which have a number of consequences on women's health. Here we assess whether adiposity at different points in the lifecourse affects reproductive factors differently and independently, and the plausibility of the impact of reproductive factors on adiposity.

Methods

We used genetic data from UK Biobank (273,238 women) and other consortia (EGG, GIANT, ReproGen and SSGAC) for eight reproductive factors: age at menarche, age at menopause, age at first birth, age at last birth, number of births, being parous, age first had sexual intercourse and lifetime number of sexual partners, and two adiposity traits: childhood and adulthood body size. We applied mu

SUBMITTER: Prince C 

PROVIDER: S-EPMC10496263 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature