Vibrational spectroscopy identifies myocardial chemical modifications in heart failure with preserved ejection fraction.

ABSTRACT:

Background

Vibrational spectroscopy can be a valuable tool to monitor the markers of cardiovascular diseases. In the present work, we explored the vibrational spectroscopy characteristics of the cardiac tissue in an experimental model of heart failure with preserved ejection fraction (HFpEF). The goal was to detect early cardiac chemical modifications associated with the development of HFpEF.

Methods

We used the Fourier-transform infrared (FTIR) and Raman micro-spectroscopic techniques to provide complementary and objective tools for the histological assessment of heart tissues from an animal model of HFpEF. A new sampling technique was adopted (tissue print on a CaF₂ disk) to characterize the extracellular matrix.

Results

Several spectroscopic markers (lip

SUBMITTER: Pioppi L 

PROVIDER: S-EPMC10496315 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature