The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury.

ABSTRACT:

Background

Preclinical studies highlight the importance of endogenous cannabinoids (endocannabinoids; eCBs) in neurodegeneration. Yet, prior observational studies focused on limited outcome measures and assessed only few eCB compounds while largely ignoring the complexity of the eCB system. We examined the associations of multiple circulating eCBs and eCB-like molecules with early markers of neurodegeneration and neuro-injury and tested for effect modification by sex.

Methods

This exploratory cross-sectional study included a random sample of 237 dementia-free older participants from the Framingham Heart Study Offspring cohort who attended examination cycle 9 (2011-2014), were 65 years or older, and cognitively healthy. Forty-four eCB compounds were quantified in serum, via l

SUBMITTER: Vered S 

PROVIDER: S-EPMC10496329 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature