Integrative analysis of the prognostic value and immune microenvironment of mitophagy-related signature for multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is a fatal malignant tumor in hematology. Mitophagy plays vital roles in the pathogenesis and drug sensitivity of MM.

Methods

We acquired transcriptomic expression data and clinical index of MM patients from NCI public database, and 36 genes involved in mitophagy from the gene set enrichment analysis (GSEA) database. Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was conducted to construct a risk score prognostic model. Kaplan-Meier survival analysis and receiver operation characteristic curves (ROC) were conducted to identify the efficiency of prognosis and diagnosis. ESTIMATE algorithm and immune-related single-sample gene set enrichment analysis (ssGSEA) was performed to uncover the level of immune infiltra

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10496355 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature