Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.

ABSTRACT:

Background

Cervical cancer is a common gynecological malignancy. Gene microarray found that TCP11 gene was highly expressed in cervical cancer. However, the effect of TCP11 gene on the proliferation, apoptosis and migration of cervical cancer cells and its underlying molecular mechanisms are unclear.

Methods

GEPIA database, tissue microarray, western blot and qRT-PCR were used to analyze the expression of TCP11 gene in cervical cancer tissues and cells and its relationship with patients' survival rate. The cell cycle and apoptosis were detected by flow cytometry, and the expressions of cell cycle and apoptosis related molecules and EMT-related molecules were detected by Western blot and qRT-PCR.

Results

The results showed that TCP11 gene was highly expressed in cervic

SUBMITTER: Wang F 

PROVIDER: S-EPMC10496356 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature