Myocardial native T₁ mapping and extracellular volume quantification in asymptomatic female carriers of Duchenne muscular dystrophy gene mutations.

ABSTRACT:

Background

Female carriers of dystrophin gene mutations (DMD-FC) were previously considered non-manifesting, but in recent decades, cardiomyopathy associated with muscular dystrophy and myocardial fibrosis has been described. Our study aimed to assess prospectively myocardial fibrosis in asymptomatic DMD-FC compared to a sex-matched control group (CG) with similar age distribution using native T₁ mapping and extracellular volume (ECV) quantification by cardiovascular magnetic resonance (CMR) imaging.

Materials and methods

38 DMD-FC with verified genetic mutation and 22 healthy volunteers were included. Using CMR, native T₁ relaxation time and ECV quantification were determined in each group. Late gadolinium enhancement (LGE) was assessed in all cases.

SUBMITTER: Masarova L 

PROVIDER: S-EPMC10496385 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature