Cuproptosis-related gene subtypes predict prognosis in patients with head and neck squamous cell carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. A novel form of copper-dependent and reactive oxygen species (ROS)-dependent cell death, cuproptosis, has been described in many cancers. The roles and potential mechanisms of cuproptosis-related genes (CRGs) are still unclear in HNSCC.

Method

We downloaded TCGA datasets of HNSCC genomic mutations and clinic data from The Cancer Genome Atlas. Based on the Cuproptosis-related differentially expressed genes in HNSCC, we constructed a prognostic signature.

Results

Eight CRGs have been identified as associated with the prognosis of HNSCC. According to Kaplan-Meier analyses, HNSCC with a high Risk Score had a poor prognosis. Furthermore, the AUC of the Risk Score for the 1-,

SUBMITTER: Wang C 

PROVIDER: S-EPMC10496405 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature