Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer's disease with multi-modal PET and plasma GFAP.

ABSTRACT:

Background

Plasma assays for the detection of Alzheimer's disease neuropathological changes are receiving ever increasing interest. The concentration of plasma glial fibrillary acidic protein (GFAP) has been suggested as a potential marker of astrocytes or recently, amyloid-β burden, although this hypothesis remains unproven. We compared plasma GFAP levels with the astrocyte tracer ¹¹C-Deuterium-L-Deprenyl (¹¹C-DED) in a multi-modal PET design in participants with sporadic and Autosomal Dominant Alzheimer's disease.

Methods

Twenty-four individuals from families with known Autosomal Dominant Alzheimer's Disease mutations (mutation carriers = 10; non-carriers = 14) and fifteen patients with sporadic Alzheimer's disease were included. The individuals under

SUBMITTER: Chiotis K 

PROVIDER: S-EPMC10496408 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature