Dexamethasone suppression for ¹⁸F-FDG PET/CT to localize ACTH-secreting pituitary tumors.

ABSTRACT:

Background

¹⁸Fluorine-Fluoro-deoxy-glucose (¹⁸F-FDG) positron emission tomography (PET) is widely used for diagnosing various malignant tumors and evaluating metabolic activities. Although the usefulness of ¹⁸F-FDG PET has been reported in several endocrine diseases, studies on pituitary disease are extremely limited. To evaluate whether dexamethasone (DEX) suppression can improve ¹⁸F-FDG PET for the localization of adrenocorticotropic hormone-secreting adenomas in the pituitary gland in Cushing's disease (CD).

Methods

We included 22 patients with CD who underwent PET imaging before and after DEX administration. We compared the success rates of PET before and after DEX suppression, magnetic resonance imaging (MRI), and bilateral in

SUBMITTER: Kim K 

PROVIDER: S-EPMC10496442 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature