Ontology highlight
ABSTRACT:
SUBMITTER: Mozhui K
PROVIDER: S-EPMC10496549 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Mozhui Khyobeni K Kim Hyeonju H Villani Flavia F Haghani Amin A Sen Saunak S Horvath Steve S
Epigenetics 20231201 1
DNA methylation is influenced by genetic and non-genetic factors. Here, we chart quantitative trait loci (QTLs) that modulate levels of methylation at highly conserved CpGs using liver methylome data from mouse strains belonging to the BXD family. A regulatory hotspot on chromosome 5 had the highest density of trans-acting methylation QTLs (trans-meQTLs) associated with multiple distant CpGs. We refer to this locus as meQTL.5a. Trans-modulated CpGs showed age-dependent changes and were enriched ...[more]