Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death.

ABSTRACT:

Background

It is unclear whether genetic variants affecting vitamin D metabolism are associated with melanoma prognosis. Two functional missense variants in the vitamin D-binding protein gene (GC), rs7041 and rs4588, determine 3 common haplotypes, Gc1s, Gc1f, and Gc2, of which Gc1f may be associated with decreased all-cause death among melanoma patients based on results of a prior study, but the association of Gc1f with melanoma-specific death is unclear.

Methods

We investigated the association of the Gc1s, Gc1f, and Gc2 haplotypes with melanoma-specific and all-cause death among 4490 individuals with incident, invasive primary melanoma in 2 population-based studies using multivariable Cox-proportional hazards regression.

Results

In the pooled analysis of both dataset

SUBMITTER: Gibbs DC 

PROVIDER: S-EPMC10496570 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature