R-type voltage-gated Ca²⁺ channels mediate A-type K⁺ current regulation of synaptic input in hippocampal dendrites.

ABSTRACT: The subthreshold voltage-gated transient K⁺ current (I_A) carried by pore-forming Kv4.2 subunits regulates the propagation of synaptic input, dendritic excitability, and synaptic plasticity in CA1 pyramidal neuron dendrites of the hippocampus. We report that the Ca²⁺ channel subunit Cav2.3 regulates I_A in this cell type. We initially identified Cav2.3 as a Kv4.2-interacting protein in a proteomic screen and we confirmed Cav2.3-Kv4.2 complex association using multiple techniques. Functionally, Cav2.3 Ca²⁺-entry increases Kv4.2-mediated whole-cell current due to an increase in Kv4.2 surface expression. Using pharmacology and Cav2.3 knockout mice, we show that Cav2.3 regulates the dendritic gradient of I_A. Furthermore, the loss

SUBMITTER: Murphy JG 

PROVIDER: S-EPMC10496648 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature