A Cu@ZIF-8 encapsulated antibacterial and angiogenic microneedle array for promoting wound healing.

ABSTRACT: Skin wounds caused by external injuries remain a serious challenge in clinical practice. Wound dressings that are antibacterial, pro-angiogenic, and have potent regeneration capacities are highly desirable for wound healing. In this study, a minimally invasive and wound-friendly Cu@ZIF-8 encapsulated PEGDA/CMCS microneedle (MN) array was fabricated using the molding method to promote wound healing. The MNs had good biocompatibility, excellent mechanical strength, as well as strong antibacterial properties and pro-angiogenic effects. When incubated with H₂O₂, Cu@ZIF-8 nanoparticles generated reactive oxygen species, which contributed to their antibacterial properties. Due to the oxidative stress of the cupric ions released from Cu@ZIF-8 and the anti-bacterial capabilit

SUBMITTER: Xiang J 

PROVIDER: S-EPMC10496905 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature