SART3, regulated by p53, is a biomarker for diagnosis, prognosis and immune infiltration in hepatocellular carcinoma.

ABSTRACT:

Objective

This study aimed to investigate the role of squamous cell carcinoma antigen recognized by T cells 3 (SART3) in hepatocellular carcinoma (HCC).

Methods

SART3 expression and prognostic value were analyzed in TCGA and GEO datasets. The diagnostic value and prognostic significance of SART3 were determined using immunohistochemistry in the Guangxi cohort. The whole-exome mutation spectrum of SART3 was analyzed in high and low expression groups in both TCGA and Guangxi cohorts. The biological functions of the SART3 gene were validated through in vitro experiments using small interfering RNA technology to downregulate SART3 expression in HCC cell lines.

Results

SART3 expression was significantly higher in HCC tissues than in adjacent noncancerous liver tissu

SUBMITTER: Nong J 

PROVIDER: S-EPMC10496991 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature