TNFR2 promotes pancreatic cancer proliferation, migration, and invasion via the NF-κB signaling pathway.

ABSTRACT:

Purpose

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant disease with low overall survival; chemotherapy and immunotherapy have limited efficacy. Tumor necrosis factor receptor 2 (TNFR2), a type II transmembrane protein, contributes to the development and progression of several tumors. In this study, we elucidated the effect and molecular mechanisms of TNFR2.

Method

We used The Cancer Genome Atlas and the Genotype-Tissue Expression database to compare the expression of the TNFR2 gene between normal and malignant pancreatic tissue. Using immunohistochemical staining, we divided the patients into high and low-expression groups, then investigated clinicopathologic data and survival curves of pancreatic cancer patients. We measured TNFR2 protein expressio

SUBMITTER: Gao Z 

PROVIDER: S-EPMC10497022 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature