Low-Dose Naltrexone Use in Postural Orthostatic Tachycardia Syndrome: A Case Series.

ABSTRACT: Introduction In recent years, low-dose naltrexone has emerged as a novel off-label therapy for many chronic conditions including postural orthostatic tachycardia syndrome (POTS), however, there is little evidence for its efficacy. Methods In this institutional review board (IRB)-approved case series, the charts of six tilt table-confirmed patients with POTS who underwent a trial of low-dose naltrexone (LDN) at our institution were reviewed. Medical history, subjective description of symptom severity, the continuation of therapy, tolerability, and scores on patient-reported outcome measures (Patient-Reported Outcomes Measurement Information System {PROMIS} Fatigue, PROMIS physical and mental health, Generalized Anxiety Disorder Assessment {GAD}-7, Patient Health Questionnaire {PHQ}-9, and C

SUBMITTER: Stallkamp Tidd SJ 

PROVIDER: S-EPMC10497067 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature