Association of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complications.

ABSTRACT:

Objectives

Mitsugumin 53 (MG53) is a myokine that acts as a membrane repair protein in tissues. Data on the effect of MG53 on insulin signaling and type 2 diabetes mellitus (T2 DM) are still unknown; most are from preclinical studies. Nevertheless, some researchers have argued that it may be a new pathogenic factor, and therapies targeting MG53 may be a new avenue for T2 DM. Our study aims to evaluate the relationship of circulating MG53 levels with the presence of diabetes, diabetic complications, and glycemic control.

Methods

We conducted a case-control study with 107 patients with T2 DM and 105 subjects without insulin resistance-related disease. Concurrent blood samples were used for serum MG53 levels and other biochemical laboratory data. MG53 concentration was measured

SUBMITTER: Andac B 

PROVIDER: S-EPMC10497120 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature