Elevated representational similarity of voluntary action and inhibition in Tourette syndrome.

ABSTRACT: Many people with Tourette syndrome are able to volitionally suppress tics, under certain circumstances. To understand better the neural mechanisms that underlie this ability, we used functional magnetic resonance neuroimaging to track regional brain activity during performance of an intentional inhibition task. On some trials, Tourette syndrome and comparison participants internally chose to make or withhold a motor action (a button press), while on other trials, they followed 'Go' and 'NoGo' instructions to make or withhold the same action. Using representational similarity analysis, a functional magnetic resonance neuroimaging multivariate pattern analysis technique, we assessed how Tourette syndrome and comparison participants differed in neural activity when choosing to make or to with

SUBMITTER: Rae CL 

PROVIDER: S-EPMC10497185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature