Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers.

ABSTRACT:

Background

The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).

Methods

In this international, double-blind, placebo-controlled trial, we randomly assigned health care workers to receive the BCG-Denmark vaccine or saline placebo and followed them for 12 months. Symptomatic Covid-19 and severe Covid-19, the primary outcomes, were assessed at 6 months; the primary analyses involved the modified intention-to-treat population, which was restricted to participants with a negative test for severe acute respiratory syndrome coronavirus 2 at baseline.

Results

A total of 3988 participants underwent randomization; recruitment ceased before the planned sample size w

SUBMITTER: Pittet LF 

PROVIDER: S-EPMC10497190 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature